Displaying 101 - 150 of 694
Uni Prot Protein Name Long Description Canonical Function GO Moonlighting Function GO Moon Organism Human Disease Drugs Induction PDBs PDB UniProt Models Reference
E7C160 60 kDa chaperonin Chaperone: Prevents misfolding and promotes the refolding and proper assembly of More ... GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:InterPro.
More ...
Insect neurotoxin GO:0008150;P:biological_process
GO:0051704;P: multi-organism process
GO:0044419; More ...
Enterobacter aerogenes (Aerobacter aerogenes) 1aon_A(97) Phyre 11333970
E9BTJ1 Fructose-bisphosphate aldolase D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate More ... GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
GO:0006 More ...
This enzyme is secreted and imported into the cytoplasm of infected macrophages, More ... GO:0003674 molecular_function
GO:0005515 protein binding
GO:0019899 enzyme bindi More ...
Leishmania donovani 2qap_A(97) Phyre 20159964
F2QC85 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate GO:0046538; F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity More ... Binding to plasmin(ogen) GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus oralis 1rii_A(57) Phyre 18310038
F2QDA9 Enolase Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruva More ... GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Binding to plasmin(ogen) GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus oralis 1w6t_A(96) Phyre 21072208
F2QDT8 ATP-dependent 6-phosphofructokinase Phosphofructokinase GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003872; F:6-phosphofructokin More ...
Plasminogen binding GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus oralis 3u39_A(70) Phyre 18310038
F2QEP1 Triosephosphate isomerase D-glyceraldehyde 3-phosphate = glycerone phosphate. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004807; F:triose-phosphate i More ...
Plasminogen binding. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus oralis 3m9y_A(65) Phyre 18310038
F2QGM8 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0051287; F:NAD binding; IEA:InterPro.
GO:0050661; F:NADP binding; IEA:InterPr More ...
Binds major fimbriae of Porphyromonas gingivalis.
Binding to Plasminogen.
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus oralis 5m6d_A(99) Phyre 19737900
F4NP01 S1 Ribosomal protein GO:0005829; C:cytosol; IDA:EcoCyc.
GO:0022625; C:cytosolic large ribosomal subun More ...
Replication GO:0003674 molecular_function
GO:0005488 binding
GO:1901363 heterocyclic compoun More ...
Escherichia coli 2bh8_A(100) Phyre 8871397
F5CUQ4 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of do More ... Role in extracellular polysaccharide synthesis GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Xanthomonas campestris pv. Leersiae 4p8r_A(82) Phyre 19372163
F5WV05 Glyceraldehyde-3-phosphate dehydrogenase Glycolisis GO:0000015; C:phosphopyruvate hydratase complex; IEA:InterPro.
GO:0000287; F:mag More ...
Adhesin. Binding to fibronectin and plasminogen. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Erysipelothrix rhusiopathiae 3cmc_O(67) Phyre 28327178
F9VMT6 Fructose-1,6-bisphosphatase Fructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosp More ... Fructose-1,6-bisphosphatase, phosphatase, aldolase Fructose-1,6-bisphosphatase, phosphatase GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016829 lyase act More ...
Sulfolobus tokodaii 3r1m_A(100) 1umg_A (100), 3r1m_A (100) Phyre 21983966
F9VMT6 Fructose-1,6-bisphosphatase Embden–Meyerhof
pathway
GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-EC More ... Fructose-1,6-
bisphosphate
phosphatase
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Sulfolobus tokodaii 3r1m_A(100) 1umg_A (100), 3r1m_A (100) Phyre 21983966
F9XY86 Enolase Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruva More ... GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Binding to plasmin(ogen) GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Bifidobacterium breve 4yws_A(66) Phyre 19574304
G5L1C5 6-phosphogluconate dehydrogenase Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phos More ... GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:Uni More ... Adhesion to host, unknow receptor. GO:0008150 biological_process
GO:0051704 multi-organism process
GO:0044419 inter More ...
Streptococcus suis Phyre 14688145
G6C746 Phosphoglycerate kinase EC:2.7.2.3 It converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate (glycolysis More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:U More ...
Plasminogen binding protein in oral streptococci. In group B streptococci cell s More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus sp. oral 3zlb_A(97) Phyre 18194256
G6FCR9 ATP-dependent 6-phosphofructokinase Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosp More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003872; F:6-phosphofructokin More ...
Binding to invertase, a mannoprotein of Saccharomyces GO:0008150 biological_process
GO:0022610 biological adhesion
GO:0003674 molecula More ...
Lactococcus lactis Phyre 19898842
G6LM38 Choline binding protein E Surface proteins noncovalently bound to the phosphorylcholine moiety of the cell More ... GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. Virulence (colonization of the nasopharynx) GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Streptococcus pneumoniae Phyre 10992472
I3WHD5 Enolase Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruva More ... GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Binding to plasmin(ogen) GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Bifidobacterium bifidum 4yws_A(64) Phyre 19574304
I4E817 Fructose-1,6-bisphosphate aldolase Glycolysis GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
GO:0008 More ...
Adhesion to host. GO:0008150 biological_process
GO:0051704 multi-organism process
GO:0044419 inter More ...
Neisseria meningitidis 2isw_A(54) Phyre 20199602
I6L8L9 Glyceraldehyde-3-phosphate dehydrogenase Glycolisis GO:0051287; F:NAD binding; IEA:InterPro.
GO:0050661; F:NADP binding; IEA:InterPr More ...
Binds to peptidoglycan. Cells depends on the LytA-mediated lysis of a fraction o More ... GO:0003674 molecular_function
GO:0005488 binding
GO:0097367 carbohydrate der More ...
Streptococcus pneumoniae 3cmc_O(58) 5m6d_A/B (100) Phyre 25927608
I7MG78 Citrate synthase EC:2.3.3.1 It catalyzes the condensation reaction from acetyl coenzyme A and a molecule of More ... GO:0046912; F:transferase activity, transferring acyl groups, acyl groups conver More ... 14 nm cytoskeletal protein (structural filament - forming protein) GO:0003674 molecular_function
GO:0005488 binding
GO:0060090 molecular adaptor ac More ...
Tetrahymena thermophila 1al6_A(75) Phyre 8575889
J0Q2D7 Serine protease HtrA Serine protease GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. Binding to e-cadherin GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO:0 More ...
Helicobacter pylori 3cs0_A(67) Phyre 20814423
J1NX65 PPI (Peptidyl Prolyl cis,trans-Isomerase (PPI) EC:5.2.1.8) PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomeriza More ... GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
GO More ...
Adhesion to host, unknow receptor. GO:0008150 biological_process
GO:0022610 biological adhesion
Streptococcus pneumoniae 2a2n_A(66) Phyre 16260779
J7M6M6 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0051287; F:NAD binding; IEA:InterPro.
GO:0050661; F:NADP binding; IEA:InterPr More ...
Fibronectin binding protein - Plasminogen binding protein - Cell signaling kinas More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus pyogenes 4qx6_A(91) Phyre 1500854
J7R5H8 Aspartate receptor Aspartate receptor (mediate chemotactic response in certain enteric bacteria, me More ... GO:0016021; C:integral component of membrane; IEA:InterPro.
GO:0004888; F:transm More ...
Maltose-binding -protein receptor GO:0003674 molecular_function
GO:0005488 binding
GO:0030246 carbohydrate bindin More ...
Escherichia coli 2l9g_A(100) Phyre 3049535
L8DW58 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0047100;glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) ac More ... Binding to Plasminogen GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Listeria monocytogenes Phyre 24833341
M1XHM3 Ornithine carbamoyltransferase Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCel
GO:0016597; F:amino acid binding; More ...
Fibronectin binding GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Staphylococcus epidermidis Phyre 10569792
M3Y807 Glucose-6-phosphate isomerase Catalyzes interconversion of glucose-6-phosphate and fructose-6-phosphate in gly More ... GO:0060170; C:ciliary membrane; IEA:Ensembl.
GO:0005737; C:cytoplasm; IEA:Ensemb More ...
Secreted cytokine/growth factor/endocrine necessary for embryo implantation in t More ... GO:0008150 biological_process
GO:0000003 reproduction
GO:0032502 developmental p More ...
Mustela nigripes 1gzd_A(94) Phyre 15201066
M4ZD78 Enolase Glycolysis GO:0000015; C:phosphopyruvate hydratase complex; IEA:InterPro.
GO:0000287; F:mag More ...
Plasminogen binding. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus dysgalactiae subsp equisimilis Phyre 8706717
O00337 Sodium/nucleoside cotransporter 1 Nucleosides Transport (selective for pyrimidine nucleosides and adenosine) GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO:0016020; More ...
Inhibition of tumor growth (likely to be relevant in tumor biology) GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Homo sapiens Concentrative nucleoside transporter deficency (omim:606207) Gemcitabine, Zidovudine, Stavudine 3tij_A(53) Phyre 23722537
O13289 Peroxisomal catalase Occurs in almost all aerobically respiring organisms and serves to protect cells More ... GO:0005829; C:cytosol; IBA:GO_Central.
GO:0016491; F:oxidoreductase activity; ID More ...
Plasminogen binding GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Candida albicans 2xq1_A(79) Phyre 12622818
O14786 Neuropilin (VEGF receptor) Vascular endothelial cell growth factor receptor GO:0030424; C:axon; ISS:BHF-UCL.
GO:0009986; C:cell surface; IEA:Ensembl.
GO:003 More ...
Receptor for semaphorin III (nerve axons) / VEFGR, regulation of angiogenesis GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0060089; F:mo More ...
Homo sapiens DiGeorge syndrome (omim:188400) Anti-NRP1, RG7347 4gz9_A(92) 1kex_A (100), 2qqi_A (100), 2qqm_A (100), 2qqn_A (100), 3i97_A/B (100), 4deq_A/B More ... Phyre 9529250
O15105 Mothers against decapentaplegic homolog 7 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor More ... GO:0005813; C:centrosome; IDA:HPA.
GO:0005737; C:cytoplasm; IDA:BHF-UCL.
GO:0005 More ...
Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its d More ... GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO:0 More ...
Homo sapiens Colorectal cancer 3 (CRCS3) (omim:612229) 2DJY 2djy_B (100), 2kxq_B (100), 2ltv_B (100), 2ltw_B (100), 2ltx_B (100), 2lty_B (10 More ... Phyre 26499805
O29116 Helicase Helicase (to separate strands of a DNA double helix) to unwind damaged DNA GO:0005524; F:ATP binding; IEA:InterPro.
GO:0004386; F:helicase activity; IEA:Un More ...
Helicase to initiate transcription GO:0008150 biological_process
GO:0071840 cellular component organization or biog More ...
Archaeglobus fulgidus Phyre 16600867
O30298 Fructose-1,6-bisphosphatase/inositol-1-monophosphatase myo-Inositol biosynthesis
and
NADP(H) phosphatase
GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-EC More ... Fructose 1,6-
bisphosphatase
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Archaeoglobus fulgidus 1lbv_A(100) 1lbv_A/B (100), 1lbw_A/B (100), 1lbx_A/B (100), 1lby_A/B (100), 1lbz_A/B (100), More ... Phyre 11940584
O33983 Amidase Autolysin GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
GO:0009 More ...
Adherence to eukaryotic cells GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Listeria monocytogenes 1m9s_A(71) Phyre 10746777
O34097 Surface protein pspA N-acetylmuramoyl-L-alanine amidase activity GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolas More ...
Inhibition of complement activity in host Inhibits CRP deposition and C3 convert More ... GO:0008150 biological_process
GO:0065007 biological regulation
GO:0008152 metabo More ...
Streptococcus pneumoniae 1h8g_A(62) Phyre 28265264
O34529 Phosphofructokinase EC:2.7.1.11 Conversion of Fructose-6-phosphate to Fructose-1,6-bisphosphate (Glycolysis) GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003872; F:6-phosphofructokin More ...
Interactions with RNA processing enzymes & Part of RNA degradosome complex GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Bacillus subtilis 4a3s_A(100) 4a3s_A/B (100) Phyre 19193632
O43541 Mothers against decapentaplegic homolog 6 Acts as a mediator of TGF-beta and BMP antiflammatory activity. GO:0005737; C:cytoplasm; TAS:BHF-UCL.
GO:0005829; C:cytosol; IDA:HPA.
GO:0005794 More ...
May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-a More ... GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO: More ...
Homo sapiens Aortic valve disease 2 (AOVD2) (omim:614823) Phyre 26499805
O49562 Pyruvate, orthophosphatedikinase regulatory protein (PPDK-RP) PEP synthesis,C4 photosynthesis GO:0009507; C:chloroplast; IDA:TAIR.
GO:0009570; C:chloroplast stroma; IEA:UniPr More ...
Catalyzes light-dependent dephosphorylation (activation) or dark-induced phospho More ... GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Arabidopsis thaliana 5d0n_A(68) Phyre 11950985
O51312 Enolase EC:4.2.1.11 Conversion of 2-phosphoglycerate to phosphoenolpyruvate (Glycolysis) GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Binding to plasminogen. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Borrelia burgdorferi 4a3r_A(64) Phyre 16485259
O53166 Aconitase EC:4.2.1.3 Catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aco More ... GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0051539; F:4 iron, 4 sulf More ...
Trans-responsive protein & Iron-dependent RNA-binding activity GO:0003674; F:molecular function.
GO:0005488; F:binding.
GO:0003676; F:nucleic More ...
Mycobacterium tuberculosis 3sn2_A(68) Phyre 17384188
O54288 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldola More ... Involved in the degradation of glucose and galactose via the Entner-Doudoroff pa More ... GO:0008674; F:2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity; IDA:UniP More ... It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphog More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Sulfolobus solfataricus 1w3i_A(100) 1w37_A/B/C/D (100), 1w3i_A/B/C/D (100), 1w3n_A/B/C/D (100), 1w3t_A/B/C/D (100), More ... Phyre 15869466
O59394 Isocitrate--homoisocitrate dehydrogenase Homoisocitrate
dehydrogenase
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.
GO:0033708 More ...
May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitra More ... GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Pyrococcus horikoshii 1a05_A(66) Phyre 23283522
O60568 Lysyl hydroxylase isoform 3 EC:1.14.11.4 Lysyl hydroxylase GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0070062; C:extrac More ...
Collagen glucosyltransferase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Homo sapiens Lysyl hydroxylase 3 deficiency (LH3 deficiency) 6fxk_A (100), 6fxm_A (100), 6fxr_A (100), 6fxt_A (100), 6fxx_A (100), 6fxy_A (10 More ... Phyre 10934207
O64903 Nucleoside diphosphate kinase (NDPK2) EC:2.7.4.6 Major role in the synthesis of nucleoside triphosphates other than ATP GO:0009507; C:chloroplast; IDA:TAIR.
GO:0009941; C:chloroplast envelope; IDA:TAI More ...
Phytochrome-mediatedsignal transduction
May be involved in the regulation of cel More ...
GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Arabidopsis thaliana 1s57_A(100) 1s57_A/B/C/D/E/F (100), 1s59_A/B/C/D/E/F (100) Phyre 12506203
O69174 Enolase EC:4.2.1.11 Conversion of 2-phosphoglycerate to phosphoenolpyruvate (Glycolysis) GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Laminin binding protein.
Binding to plasmin(ogen).
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Staphylococcus aureus 5boe_A(100) 5boe_A/B (100), 5bof_A/B (100) Phyre 15158195
O75390 Citrate synthase, mitochondrial Citrate synthase GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO:0005759; C:mitochondrial More ...
RNA binding protein. GO:0003674 molecular_function
GO:0005488 binding
GO:1901363 heterocyclic compo More ...
Homo sapiens <a href=""https://www.drugbank.ca/biodb/bio_entities/BE0004459"">Trifluoroaceton More ... 3enj_A(96) 5uzp_A/B (100), 5uzq_A (100), 5uzr_A/D (100) Phyre 26520658
O75925 PIAS1 Inhibition of activated STAT GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; T More ...
Activation of p53 GO:0008150 biological_process
GO:0065007 biological regulation
regulation of res More ...
Homo sapiens Cancer (omim:603566) 4mvt_A(81) 1v66_A (100) Phyre 10805787
O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic (Phosphoribosyl More ... Histidine synthesis (Phosphoribosyl-ATP Pyrophosphohydrolase) GO:0009507; C:chloroplast; IDA:TAIR.
GO:0009570; C:chloroplast stroma; IDA:TAIR. More ...
Phosphoribosyl-AMP Cyclohydrolase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Arabidopsis thaliana Phyre 9733547