Displaying 601 - 650 of 694
Uni Prot Protein Name Long Description Canonical Function GO Moonlighting Function GO Moon Organism Human Disease Drugs Induction PDBs PDB UniProt Models Reference
Q8LPN3 PABA–GATase (p-Aminobenzoate synthase–glutamine-amidotransferase) Glutamine-amidotransferase GO:0009507; C:chloroplast; IDA:TAIR.
GO:0046820; F:4-amino-4-deoxychorismate syn More ...
Glutamine-cyclase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Arabidopsis thaliana 1k0e_A(60) Phyre 9654139
Q8R010 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Scaffold protein in the multisynthase complex forms a multi-protein complex with More ... GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; ISO:MGI.
G More ...
Binds to FUSE-binding protein (FBP), a transcriptional activator of c-myc the pr More ... GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008134 transcriptio More ...
Mus musculus 5a34_B(87.4) Phyre 12819782
Q8RWT5 Phosphoribosylaminoimidazolecarboxamideformyltransferase–IMP cyclohydrolase (AIC More ... IMP synthesis GO:0009507; C:chloroplast; IDA:TAIR.
GO:0009570; C:chloroplast stroma; IDA:TAIR. More ...
Catalyzes last two steps in purine synthesis GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Arabidopsis thaliana 3zzm_A(58) Phyre 11891236
Q8SY83 ESCRT-II complex Sorting ubiquitinated endosomal proteins into internal vesicles GO:0000815; C:ESCRT III complex; ISS:FlyBase.
GO:0032509; P:endosome transport v More ...
Bicoid mRNA localization GO:0000003; P:reproduction. Synonyms: reproductive physiological process.
GO:001 More ...
Drosophila melanogaster Phyre 17268469
Q8U085 Carbamoyl-phosphate synthase large chain Carbamoyl phosphate
synthesis
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004088; F:carbamoyl-phosphate s More ...
Carbamate kinase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Pyrococcus furiosus 1a9x_A(70) Phyre 23283522
Q8U3L0 Thermostable carboxypeptidase 1 Broad specificity carboxypetidase that releases amino acids sequentially from th More ... GO:0050897; F:cobalt ion binding; IDA:UniProtKB.
GO:0004181; F:metallocarboxypep More ...
Aminoacylase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Pyrococcus furiosus 1k9x_A(100) 1k9x_A/B/C/D (100), 1ka2_A (100), 1ka4_A (100) Phyre 11157230
Q8W1L6 Fatty acid multifunctional protein (MFP) EC:1.1.1.35 Multifunctional enzyme involved in fatty acid beta-oxidation. Also binds to RNA More ... GO:0005618; C:cell wall; IEA:EnsemblPlants.
GO:0009507; C:chloroplast; IEA:Ensem More ...
Possible RNA- and microtubule-organizing protein GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Rice (Oryza sativa Japonica Group) and probably Arabidopsis 2wtb_A(70) Phyre 11706039
Q8WVT3 Trafficking protein particle complex subunit 12 May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a ver More ... GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtK More ... Plays a role in chromosome congression, kinetochore stability, and CENP-E recrui More ... GO:0008150 biological_process
GO:0009987 cellular process
GO:0032879 regulation More ...
Homo sapiens 5gap.1.G(13) Phyre 2591822
Q8X1T3 Pyruvate Carboxylase EC:6.4.1.1 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the co More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:U More ...
Assembly of alcohol oxidase GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Pichia angusta (Yeast) (Hansenula polymorpha & Pichia pastoris) 3bg5_A(60) Phyre 12589070
Q8X1X3 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004365; F:glyceraldehyde-3-p More ...
Binds fibronectin, laminin and type II collagen Paracoccidioides brasiliensis 3e5r_A(76) 8de5_A (100) Phyre 9092705
Q8X709 birA biotin synthetase Biotin-[acetylCoA carboxylase] holoenzyme synthetase GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
GO:0004077; F:biotin-[acetyl-CoA More ...
Bio operon repressor GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Escherichia coli 1bia_A(99) Phyre 6456358
Q8ZWV0 Bifunctional phosphoglucose/phosphomannose isomerase Catalyzes the isomerization of glucose 6-phosphate. GO:0030246; F:carbohydrate binding; IEA:InterPro.
GO:0004347; F:glucose-6-phosph More ...
Catalyzes the isomerization of epimeric mannose 6-phosphate at a similar catalyt More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Pyrobaculum aerophilum 1tzb_A(100) 1tzb_A/B (100), 1tzc_A/B (100), 1x9h_A/B (100), 1x9i_A/B (100) Phyre 15290326
Q91X52 L-xylulose reductase Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, More ... GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO:0005903; C:brush More ...
A role in cell adhesion, pointing to a novel function involving tumour progressi More ... GO:0022610; P:biological adhesion.
GO:0007155; P:cell adhesion. Synonyms: cell a More ...
Mus musculus 1pr9_B(85) Phyre 24720935
Q91X52 L-xylulose reductase Catalyzes the NADPH-dependent reduction of L-xylulose, D-xylulose, L-+ erythrulo More ... GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO:0005903; C:brush More ...
A role in cell adhesion, pointing to a novel function involving tumour progressi More ... GO:0007155; P:cell adhesion. Synonyms: cell adhesion molecule activity.
GO:00163 More ...
Caenorhabditis elegans 1pr9_B(85) Phyre 24720935
Q92211 Glyceraldehyde-3-phosphate dehydrogenase Glycolisis GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
GO:0005737; C:cytoplasm; IEA:Uni More ...
Adhesion and invasion processes (fribronectin, laminin and type I collagen bindi More ... GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Candida albicans 1gad_O(79) 7u4s_A/B/C/D (100) Phyre 25566229
Q92353 Ubp6 - Ubiquitin carboxyl-terminal hydrolase 6 Deubiquitinating cysteine protease GO:0005654; C:nucleoplasm; IDA:PomBase.
GO:0005634; C:nucleus; IDA:PomBase.
GO:0 More ...
Proteasome-inhibitory activity GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009056 catabolic More ...
Schizosaccharomyces pombe 2ayn_A(72) Phyre 17018280
Q92448 Phosphofructokinase EC:2.7.1.11 Conversion of Fructose-6-phosphate to Fructose-1,6-bisphosphate (Glycolysis) GO:0005945; C:6-phosphofructokinase complex; IEA:EnsemblFungi.
GO:0005739; C:mit More ...
Autophagy peroxisomes / Thyroid hormone binding, NTP synthesis GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Pichia pastoris 3opy_A(98) Phyre 9296392
Q93244 Cysteine synthase Catalyzes the final reaction of cysteine biosynthesis in bacteria. GO:0005737; C:cytoplasm; IDA:WormBase.
GO:0055120; C:striated muscle dense body; More ...
Transcription regulation. GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Caenorhabditis elegans 4aec_A(63) Phyre 25731080
Q93EU6 60 kDa chaperonin Prevents misfolding and promotes the refolding and proper assembly of unfolded p More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:U More ...
Associated with epithelial cell binding GO:0008150 biological_process
GO:0051704 multi-organism process
GO:0044419 inter More ...
Enterococcus faecalis 1iok_A(65) Phyre 24362949
Q95TP9 RPs6 (40S ribosomal protein S6) Ribosomal protein GO:0005840; C:ribosome; IEA:UniProtKB-KW.
GO:0003735; F:structural constituent o More ...
Regulation of development (flies with minute phenotype have delayed larval devel More ... GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Drosphila melanogaster 4v6w_AG(100) Phyre 22194697
Q968V9 Aldolase EC:4.1.2.13 Splits the fructose 1,6-bisphosphate, into dihydroxyacetone phosphate & glyceral More ... GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
GO:0006 More ...
Host cell invasive (in toxoplasma & plasmodium aldolase acts as a bridge between More ... GO:0030260; P:entry into host cell. host cell invasion.
GO:0008150;P:biological_ More ...
Plasmodium Vivax 2eph_A(89) Phyre 17426153
Q96CW1 Clathrin adaptor AP-2 Adaptor for clathrin-mediated endocytosis GO:0030122; C:AP-2 adaptor complex; TAS:BHF-UCL.
GO:0030669; C:clathrin-coated e More ...
1. Possible activity in Mitosis: Interaction with BubR1 (mitotic checkpoint kina More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Homo sapiens 2bp5_M(100) 1h6e_A (100), 6bnt_A (100), 6uri_M (100) Phyre 12419313
Q96HA1 Nuclear envelope pore membrane protein POM 121 Essential component of the nuclear pore complex (NPC). The repeat-containing dom More ... GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0016021; More ...
When overexpressed in cells induces the formation of cytoplasmic annulate lamell More ... GO:0008150 biological_process
GO:0065007 biological regulation
GO:0032502 develo More ...
Homo sapiens 5t6w_C (100) Phyre 26791761
Q96UH7 Aldolase Glycolisis GO:0005829; C:cytosol; IEA:EnsemblFungi.
GO:0005739; C:mitochondrion; IEA:Ensemb More ...
Plasminogen binding. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Paracoccidioides brasiliensis 3qm3_A(58) Phyre 25566229
Q96VN5 Triosephosphate isomerase D-glyceraldehyde 3-phosphate = glycerone phosphate. GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-EC.
GO:0006094; More ...
Adhesin GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Paracoccidioides brasiliensis 2v2h_A(58) Phyre 17714474
Q976C3 Uncharacterized N-acetyltransferase STK_02580 Nucleotide-sugar
biosynthesis
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008080; F:N-acetyltransferas More ...
GalNAc-1-P
uridyltransferase
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transfera More ...
Sulfolobus tokodaii 2x7b_A(81) Phyre 20400541
Q97QS2 Enolase EC:4.2.1.11 Conversion of 2-phosphoglycerate to phosphoenolpyruvate (Glycolysis) GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular r More ...
Plasminogen binding / plasminogen receptor, heat shock protein, cytoskeletal/chr More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus pneumoniae 1w6t_A(100) 1w6t_A/B (100) Phyre 9603964
Q97QS2 Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.12 Conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phos More ... GO:0051287; F:NAD binding; IEA:InterPro.
GO:0050661; F:NADP binding; IEA:InterPr More ...
Plasminogen binding protein / Adhesin for mucin.
Activates and depletes compleme More ...
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Streptococcus pneumoniae 5m6d_A(100) 1w6t_A/B (100) Phyre 15039372
Q97U27 D-gluconate/D-galactonate dehydratase Involved in the degradation of glucose and galactose via the branched variant of More ... GO:0008869; F:galactonate dehydratase activity; IDA:UniProtKB.
GO:0047929; F:glu More ...
It is also able to catalyze the dehydration of galactonate to produce 2-keto-3-d More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Sulfolobus solfataricus 3dip_A(62.1) Phyre 16567425
Q97UB2 Dihydroxy-acid dehydratase 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. GO:0005622; C:intracellular; IBA:GO_Central.
GO:0051539; F:4 iron, 4 sulfur clus More ...
Gluconate
dehydratase
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Sulfolobus solfataricus Phyre 23283522
Q98TD4 NADPH quinone oxidoreductase NADPH quinone oxidoreductase GO:0016491; F:oxidoreductase activity; IEA:InterPro.
GO:0008270; F:zinc ion bind More ...
Zeta crystallin GO:0003674 molecular_function
GO:0005198 structural molecule activity
GO:0005212 More ...
Hyla japonica 1yb5_A(66) Phyre 11371565
Q99217 Amelogenin Regulates the size and shape of mineral crystallites GO:0009986; C:cell surface; ISS:BHF-UCL.
GO:0005578; C:proteinaceous extracellul More ...
Mitochondrial DNA maintenance GO:0008150; P:biological_process. Synonyms: physiological process; biological pr More ... Homo sapiens Amelogenesis imperfecta hypoplastic/ hypomaturation type 1E (omim:301200) Phyre 16674683
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P More ... GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0005759; C:mitochondrial matrix; TAS:Re More ...
It may contribute to the neuronal dysfunction associated with Alzheimer disease More ... GO:0008150 biological_process
GO:0071840 cellular component organization or biog More ...
Homo sapiens 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) (omim:3 More ... 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Eth More ... 2o23_A(100) 1so8_A (100), 1u7t_A/B/C/D (100), 2o23_A/B (100), 7onu_A/B/C/D (100), 8cbk_A/B/C More ... Phyre 25925575
Q99973 Telomerase protein component 1 Component of the telomerase ribonucleoprotein complex that is essential for the More ... GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
GO:0005737; C More ...
Responsible for the localizing and stabilizing vault RNA (vRNA) association in t More ... Homo sapiens Cancer GRN163L Phyre 25567623
Q99988 Growth/differentiation factor 15 Extracellular region/Secretion protein involved in apoptosis GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0070062; C:extracellular exosome; IDA More ...
Nucleus/Gene regulation GO:0008150 biological_process
GO:0065007 biological regulation
GO:0008152 metabo More ...
Homo sapiens Cancer 3rjr.1.A(22) 5vt2_A/B (100), 5vz3_A (100), 5vz4_A (100), 6q2j_A/B (100) Phyre 26499805
Q9BPW9 hRoDH-E2 (Dehydrogenase/reductase SDR family member 9) Retinoid and hydroxy-steroid Dehydrogenase/Reductase GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0030176; C:integr More ...
Transcriptional repressor GO:0008150 biological_process
GO:0010558 negative regulation of macromolecule bi More ...
Homo sapiens Phyre 16691198
Q9CXW4 60S ribosomal protein L11 Component of the 60S ribosomal subunit GO:0005737; C:cytoplasm; ISO:MGI.
GO:0022625; C:cytosolic large ribosomal subuni More ...
Binds to and inhibits HDM2 GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Mus musculus 4d5y_J(100) 6swa_J (100), 7cpu_LJ (100), 7cpv_LJ (100), 7ls1_E1 (100), 7ls2_E1 (100) Phyre 12842086
Q9D1M4 Eukaryotic translation elongation factor 1 epsilon-1 Scaffold protein in the multisynthase complex forms a multi-protein complex with More ... GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; NAS:UniProtKB.
GO:0 More ...
Protein-protein interaction with ATM/ATR that results in p53 activation transloc More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0030234; F:en More ...
Mus musculus 2uz8_A(89) Phyre 15680327
Q9FDQ1 Surface protein PspC N-acetylmuramoyl-L-alanine amidase activity GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular regi More ...
Inhibition of C3 convertase formation and MAC assembly. Inhibition of complement More ... GO:0008150 biological_process
GO:0065007 biological regulation
GO:0008152 metabo More ...
Streptococcus pneumoniae Phyre 28265264
Q9GP32 Aldolase EC:4.1.2.13 Splits the fructose 1,6-bisphosphate, into dihydroxyacetone phosphate & glyceral More ... GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
GO:0006 More ...
It is exposed in the host–parasite interface: involvement in molecular signaling More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Echinococcus multilocularis (E. granulosus) 1fdj_A(66) Phyre 22750316
Q9H009 Nascent polypeptide-associated complex subunit alpha-2 Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmi More ... GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniPr More ...
Is involved in the ribosome biogenesis. In ALL eukaryotes cells. GO:0008150 biological_process
GO:0071840 cellular component organization or biog More ...
Homo sapiens Mutations and deletions are lethal in early development 3mcb_A(90.7) Phyre 25850291
Q9H211 DNA replication factor Cdt1 Helps load proteins onto chromatin to create the pre-replication complex for ini More ... GO:0005829; C:cytosol; TAS:Reactome.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO More ...
Role in mitosis localizes to kinetochores through binding to the Hec1 component More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Homo sapiens Meier-Gorlin syndrome 4 (omim:613804) 1wlq_C(83) 2le8_B (100), 2wvr_C (100), 6qcg_G/H/I/J/K/L (100), 8s0e_8 (100), 8s0f_8 (100) Phyre 22581055
Q9H2X9 Solute carrier family 12 member 5 K-Cl cotransporter (ion transporter) GO:0043198; C:dendritic shaft; IEA:Ensembl.
GO:0016021; C:integral component of More ...
A structural protein orchestrating the organization of the cytoskeleton in neuro More ... GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Homo sapiens Epilepsy, Hyperalgesia Potassium Chloride, Bumetanide, Drugbank test drug 3g40.1.A(15) 6m23_A/B (100), 7d8z_A/B (100) Phyre 24909111
Q9H8X2 Inositol-pentakisphosphate 2-kinase Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 More ... GO:0005829; C:cytosol; TAS:Reactome.
GO:0005622; C:intracellular; IDA:BHF-UCL.
G More ...
It is also a structural component in the nucleolus. IP5K has functionally signif More ... GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
GO:0 More ...
Homo sapiens 2xam.2.A(34) Phyre 23203802
Q9HI69 Glutamate formimidoyltransferase Glutamate formiminotransferase (Aminoacid transport and metabolism) GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0030272; F:5-formyltetrahydro More ...
5-Formyltetrahydrofolate cycloligase GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Thermoplasma acidophilum Phyre 20952389
Q9HIC2 Bifunctional phosphoglucose/phosphomannose isomerase Embden–Meyerhof
pathway
GO:0030246; F:carbohydrate binding; IEA:InterPro.
GO:0004347; F:glucose-6-phosph More ...
Phosphomannose
isomerase
GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0003824; F:ca More ...
Thermoplasma acidophilum Phyre 14551194
Q9I9A9 Iota-crystallin Lens crystallin GO:0016918; F:retinal binding; IEA:InterPro. Cellular retinol-binding protein GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Lygodactylus picturatus (Yellow-headed dwarf gecko) 1ggl_A(63) Phyre 2462567
Q9JFN4 Paramyxovirus hemagglutinin Paramyxovirus hemaglutinin GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
GO:0016021; C:integral compo More ...
Neuraminidase EC:3.2.1.18 GO:0003674 molecular_function
GO:0005488 binding
GO:0043167 ion binding
GO:00360 More ...
Tupaia paramyxovirus Phyre 11062565
Q9JVQ9 Chaperone protein DnaK Chaperone GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0006457; P:protein folding; IEA: More ...
Plasminogen binding GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Neisseria meningitidis Phyre 17307854
Q9K0N4 Chaperone protein DnaK Chaperone GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
GO:0006457; P:protein folding; I More ...
Binding to plasminogen. GO:0003674; F:molecular_function. Synonyms: molecular function.
GO:0005488; F:bi More ...
Neisseria meningitidis 2kho_A(74) Phyre 17307854